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Researchers observed that weight loss with semaglutide ranged from 9.6 to 17.1% in participants without gastrointestinal AEs and from 11.4 to 17.7% in those with gastrointestinal AEs, suggesting gastrointestinal AEs appeared to contribute little to the weight-loss benefit of semaglutide, which were consistent with previous studies that the weight-loss effects of semaglutide in patients with obesity and/or T2DM indicated little contribution of gastrointestinal AEs (26, 36, 37)

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The effect of PPAR, PPAR, PPAR, and PPARpan agonists on body weight, body mass, and serum lipid profiles in diet-induced obese AKR/J mice